JM Rojo Ortega, JM Rojo Manaute ....
Introduction.
In this paper we studied the alterations of the glomerular parietal epithelium (EPG) in spontaneously hypertensive rats (SHR) 10 and 38 weeks of age and in their normotensive controls Wistar Kyoto rats (WKY).
Material and methods. Systolic blood pressure was taken directly into the carotid artery, then the animals were sacrificed and their kidneys were processed using routine histological methods. Quantitative assessment of the EPG was made metaplasia percentage in all glomeruli counted for each animal, and separately in the glomeruli superficial and juxtamedullary. EPG metaplasia was classified according to their extension, segmental and circumferential semicircular.
results. The segmental metaplasia in WKY rats at undermining predominant juxtamedullary and consisted almost cuboidal cell type and their percentage was much higher in older rats. In SHR of 38 weeks of age metaplastic cellular pattern of EPG was often mixed (cuboidal, and columnar epithelioid) and was usually associated with semicircular forms both segmental and circumferential. The latter two also predominated in the juxtamedullary glomeruli and were very rare in control animals respectively. The cellular pattern mixed metaplastic was frequently associated with thickening of Bowman's capsule, mild to moderate inflammatory reaction pericapsular pericapsular fibrosis, desquamation of the EPG and glomerular cysts with obliteration of glomerular capillary tuft. Other pathological changes in these SHR were mainly located in the juxtamedullary and outer medulla, and consisted of hyperplasia of the media of small arteries and arterioles, some glomeruli with segmental sclerosis, tubules with proteinaceous cylinders and small foci of tubular atrophy surrounded by cells inflammatory. Except in one animal, we observed no vascular injuries in malignant nephrosclerosis.
talk. These results suggest that age in our study influence the development of segmental EPG cuboidal metaplasia and lasting hypertension with presence of tubular casts (proteinuria), may play a role in the transformation of normal EPG flattened in other cell types, including the epithelioid. This metaplasia of the EPG could participate in the development of pericapsular fibrosis, obliteration of the glomerular-tubular junction, glomerular cyst formation and progressive nephron loss, resulting in decreased renal function. http://dialnet.unirioja.es/servlet/articulo?codigo=836819&info=resumen&modo=popup
Material and methods. Systolic blood pressure was taken directly into the carotid artery, then the animals were sacrificed and their kidneys were processed using routine histological methods. Quantitative assessment of the EPG was made metaplasia percentage in all glomeruli counted for each animal, and separately in the glomeruli superficial and juxtamedullary. EPG metaplasia was classified according to their extension, segmental and circumferential semicircular.
results. The segmental metaplasia in WKY rats at undermining predominant juxtamedullary and consisted almost cuboidal cell type and their percentage was much higher in older rats. In SHR of 38 weeks of age metaplastic cellular pattern of EPG was often mixed (cuboidal, and columnar epithelioid) and was usually associated with semicircular forms both segmental and circumferential. The latter two also predominated in the juxtamedullary glomeruli and were very rare in control animals respectively. The cellular pattern mixed metaplastic was frequently associated with thickening of Bowman's capsule, mild to moderate inflammatory reaction pericapsular pericapsular fibrosis, desquamation of the EPG and glomerular cysts with obliteration of glomerular capillary tuft. Other pathological changes in these SHR were mainly located in the juxtamedullary and outer medulla, and consisted of hyperplasia of the media of small arteries and arterioles, some glomeruli with segmental sclerosis, tubules with proteinaceous cylinders and small foci of tubular atrophy surrounded by cells inflammatory. Except in one animal, we observed no vascular injuries in malignant nephrosclerosis.
talk. These results suggest that age in our study influence the development of segmental EPG cuboidal metaplasia and lasting hypertension with presence of tubular casts (proteinuria), may play a role in the transformation of normal EPG flattened in other cell types, including the epithelioid. This metaplasia of the EPG could participate in the development of pericapsular fibrosis, obliteration of the glomerular-tubular junction, glomerular cyst formation and progressive nephron loss, resulting in decreased renal function. http://dialnet.unirioja.es/servlet/articulo?codigo=836819&info=resumen&modo=popup
injuries involve the spinal cord paralysis, numbness and changes in the functioning of the bowel (urinary and rectal) and these in turn determine urinary infections, stone formation or damage to the kidneys, in the intestinal area, constipation. The man also erectile dysfunction. conservative mechanisms ensure the emptying of the bladder by catheterization or rectal cancer with drugs and maneuvers. Some drugs also facilitate the erection of the penis, but when these solutions are not satisfactory, we present time for implant systems electrostimulation of sacral nerve roots (SARS).
In this paper we present the indications and performance, comparing different surgical approaches for implantation: technique Barcelona, \u200b\u200bdesigned by our team, and the technique Extradural, considered second choice by the team that implemented the SARS in Europe.
To gauge the validity of the technique vs Barcelona. Extradural, has followed a validation methodology based on the measurement of various parameters before and after surgery. The results obtained have been applied a statistical treatment according to the test t test to analyze statistical significance.
We compare the composition of the general group of SARS (60 patients) with the general population (control group, consisting of 2,550 spinal cord injury treated between 1990 and 2000, Guttmann Institute) to know their representativeness. SARS group is younger, but more serious injuries and typology almost equal for men than for women.
applicability of the study gives a comparison between techniques, showing no significant differences between them in clinical parameters.
In efficacy studies, it appears that there is no difference, both clinically and on aspects quality of life, assessed by the test SIP (Sickness Impact Profile test) and that scores on perceptions of welfare are higher than the control group of 250 spinal injuries who come to her regular medical check, no gross pathology.
In the discussion, we compare the results of the technique and Extradural Barcelona, \u200b\u200bwith those reported in the literature, obtained by expressing the original Intradural technique. Our series is among the best published.
is concluded validating and recommending the strategy and Extradural Barcelona, \u200b\u200bwhich are complementary to the implant of SARS in paraplegic patients, definitive treatment of disorders sphincter.
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